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kalimuscle   , 19

from Hyde Park


Dihydrotestosterone - The Key Element in Male Hair Loss

Dihydrotestosterone (DHT) is a potent and highly lively androgen implicated for man pattern hair loss. Dihydrotestosterone is produced generally in the prostate gland, testes, adrenal glands and hair follicles. The organization of dihydrotestosterone involved testosterone as a prohormone. Testosterone is metabolized by either of the two types of isoenzymes: 5-alpha reductase type I and 5-alpha reductase type II changing it to a more active dihydro- form.


Androgen target tissue are the sites of dihydrotestosterone formation which include the androgen dependent and androgen sensitive regions in the body. In the androgen sensitive region, the nuclear membrane and microsomes are involved in the conversion process. Although, testosterone masteron is produced mainly in the examen, production of dihydrotestosterone occurs anywhere in the body where testosterone has entered the cells of the vom männlichen geschlechtshormon dependent tissue. Within the scalp, the androgen dependent areas include the frontotemporal region, the crown and the vertex. Essentially, these are the sites where hair fall occurs at the onset of male pattern tresses loss.

Dihydrotestosterone and Man Pattern Hair Loss

Within the androgen dependent locations on the scalp, androgenic hormone or testosterone is converted to dihydrotestosterone. Dihydrotestosterone then binds to the androgen receptors in the hair follicles. The androgen receptors actually bind both testosterone and dihydrotestosterone. However, the dihydro- form has higher affinity to and dissociates more slowly from the receptors. Thus, higher levels of the junk are retained in the receptors. The occurrence of the androgens in the hair follicles actually facilitates hair growth. However, in genetically predisposed individuals, high levels of DHT can prevent hair growth, even completely stopping it. As a result, the damaged area on the remaining hair slowly but surely thins and may turn completely bald. Even if baldness has not yet occurred, the influenced may still look balding because of progressive miniaturization of hair. Normally, this type of hair loss starts during puberty where the body produces high levels of testosterone.

Dihydrotestosterone can only exert their negative effects on susceptible individuals. Male pattern tresses loss is heritable. Individuals who inherit the gene that predisposes the situation become susceptible to the action of DHT. They are likely to experience hair losing during puberty nevertheless they may well not really notice it until after thirty where considerable level of hair was lost. The condition influences more than 50 % of men, but the same condition is also discovered in women.

At present, the male routine hair loss has no cure. Affected individuals, however, can find treatments that can stop hair reduction effectively. Since the role of DHT has been recognized and widely accepted, the suggested treatment for the condition is the one that addresses the situation with DHT. The DHT levels on the scalp should be maintained at levels where it cannot harm the hair follicles. This can be created by instituting treatments that block the creation of the hormone such as treatments that prevent the enzyme that catalyzes the conversion process. The particular drugs minoxidil and finasteride are known as DHT blockers because they work mainly by blocking the conversion process. Both drugs are proven effective in stopping male pattern curly hair loss. They can also decide for natural treatments that blocks DHT and promotes hair regrowth.