Injury to the Area
As stated by the American Association for Pediatric Ophthalmology and Strabismus, periorbital cellulitis can result from the spread of an infection that originates in the sinuses located near the nose. The bony tissues between the orbit and the sinuses aren't quite thick, so the disease can spread to the eyelid tissues. But most cases of sinusitis do not trigger periorbital infections.
Infection from the Blood
Bacteria in the abscess can go to adjoining tissues in the face. Bacteria involved in this type of infection include Bacteroides and Fusobacterium, according to Christopher S. Kennedy and Mary E. Moffatt in the 2005 publication "Harwood-Nuss' Clinical Practice of Emergency Medicine: 4th Edition."
Any injury that breaks skin in the eyelid region may lead to periorbital cellulitis, as stated by the U.S. National Library of Medicine. A scratch to an insect or animal bite or the eyelid can enable bacteria to enter the tissues of the eye lid, causing an illness. modest wound may also lead to an infection of the eyelid tissues. Bacteria that are typically located on your skin, including Staphylococcus aureus and Staphylococcus epidermidis, may be the cause of these infections, according to EBMedicine.net. Careful monitoring of eyelid or facial injuries can prevent advancement and immediate infection.